Effect of male health on sperms

Sperm cells are the smallest cells produced by the human body, at only 50 micrometers long.But a single sperm cell contains a complete copy of all the data found on 23 chromosomes,
which can be hundreds of megabytes of information.
Even your fancy new micro SD card can’t compete with that kind of storage density.And thanks to a study published this week in the journal Cell Metabolism, we now know that sperm carries not just genetic information, but epigenetic information as well.Your DNA contains most of the instructions for making you, organized into genes, and
all those genes together make up your genome.
But even though each cell gets a complete copy of that genome, it only needs to usecertain parts — and it figures out which parts based on your epigenetic information.It needs the help, because your DNA is an incredibly complex molecule — and it’s
also really, REALLY long.
If you stretched out a single molecule of your DNA? It would be two meters long!So, how do you squeeze a two meter long molecule inside the nucleus of a cell? You wrap the DNA tightly around a long filament of protein called histone. Coiling the molecule into
a spring like that compresses it down.
But it also introduces a new problem: your DNA is wrapped SO tightly around the histone that your cell can’t access most of your genetic information anymore.So, in addition to histone and DNA, you also have epigenetic markers.“Epigenetic” literally means “above your genes.” And those epigenetic markers
sit right on top of your DNA.
They tell the cell where to coil the DNA tighter, and where to let it unspool. Unspool the DNA,and the cell can read the genes in that location. Tighten up the coil, and the genes there won’t be expressed in that cell.
It’s part of the reason that, say, a neuron becomes a neuron, and not a muscle cell — those cells carry different epigenetic data.
The neuron reads the parts of your DNA that tell it how to be a neuron, and not the parts that would tell it how to be a muscle cell.
That’s how powerful epigenetic markers can be — and they can change based on how you live your life. Your weight, diet, stress levels, and even your moods can alter those markers.We also know that they’re inherited, but for a long time, geneticists thought that sperm cells were too small to contain both the genome AND the epigenetic information of the donor.And while some studies in the past have suggested this might not be the case for mice, there hasn’t been much research into the human side of things.Sperm cells were believed to be inert carriers of DNA, so scientists just…never really
looked into it.
Until now! In this study, a group of researchers from the University of Copenhagen were specifically looking at the differences in the sperm cells
between lean and obese men.
And what they discovered was that those sperm cells not only contained epigenetic markers,but they contained DIFFERENT epigenetic markers depending on whether the donor was lean or obese.
Specifically, there were differences at the gene regions associated with appetite control.The team compared sperm cells from 13 lean men and 10 obese men, and then tracked 6 men who were going through weight-loss surgery, to see how the weight loss affected their sperm.On average, five thousand changes to sperm DNA were found between samples from before the surgery and a year after.
Well, the differences in those sperm cells were found not in the structure of the DNA or in the histones — they were in a different, related kind of molecule, called small RNA.And turns out that small RNA can also act as an epigenetic marker, by telling the cell which genes to turn on and off.
For decades, scientists believed that RNA molecules only functioned as messenger molecules,carrying information to different parts of your cells.Then, in 1998, geneticists discovered that some RNA molecules play a huge role in silencing your genes. They can prevent genes from being expressed — making them an epigenetic marker.They detect certain groups of instructions in your DNA, and then just clip onto them,
so the cell can’t access them.
And in the men in the study, they clipped onto different parts of the DNA, depending if they were lean or obese.
Women who want to have a child hear a lot of health recommendations, both before and after they get pregnant: things like maintain a healthy weight, don’t smoke, stay away from alcohol and drugs — because that could potentially affect the health of the child, even before conception occurs.
And at least part of the reason is that these things can change epigenetic markers, which then get passed on.
But according to the lead author on the study, these results tell us that prospective fathers might want to take care of themselves, too.

Effect of male health on sperms

New medicines and anti-biotics from exotic creatures!

Antibiotics are one of humankind’s most amazing discoveries. Ever since that fateful day in 1928 when Scottish physician Alexander Fleming noticed a funny mold growing in one of his
petri dishes, antibiotics have been kicking bacterial butt.
That famous mold, of course, was producing penicillin, the founding antibiotic superstar,
which has since extended the average human life by at least a decade. It fundamentally
changed the face of medicine. Antibiotics, or antimicrobials, are basically selective
poisons designed to either kill or slow the growth of bacteria to the point where your
body’s own immune system can clean up. These drugs target a specific part of bacteria or
some important stage in their development without damaging the body’s host cells. And
they’re really great their job. Until they aren’t.

Continue reading “New medicines and anti-biotics from exotic creatures!”

New medicines and anti-biotics from exotic creatures!

Nobel prize for brain lobotomy!!

Science can be …. complicated.
And I don’t mean all the math that’s involved. Or the jargon. Or the fact that you can do
an experiment a dozen times and not get the same results twice.
I’m just saying it can be … dicey.
Like, we’ve told you before about Fritz Haber, the chemist who developed the technology
that made fertilizer possible, and helped feed millions of people.
Except he didn’t use his discovery for that. He used it to invent chemical weapons. Continue reading “Nobel prize for brain lobotomy!!”

Nobel prize for brain lobotomy!!